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Neurofilament light chain (NfL), is a non-specific biomarker for several neurodegenerative conditions, including Alzheimer’s disease, multiple sclerosis, and amyotrophic lateral sclerosis (ALS). The new, plasma-based, assay can determine if cognitive decline may be related to a neurodegenerative condition. "Neurofilament light …Neurofilament light chain (NfL), is a non-specific biomarker for several neurodegenerative conditions, including Alzheimer’s disease, multiple sclerosis, and amyotrophic lateral sclerosis (ALS). The new, plasma-based, assay can determine if cognitive decline may be related to a neurodegenerative condition. "Neurofilament light …We found robust increases of neurofilament light chain (NfL) in CSF and blood in murine models of α-synucleinopathies, tauopathy, and β-amyloidosis. Blood and CSF NfL levels were strongly correlated, and NfL increases coincided with the onset and progression of the corresponding proteopathic lesions in brain. Experimental induction of …

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